Organic Acids
Medchemexpress LLC Cyclorasin 9A5 (TFA) | 1782098-79-6 | 99.57% | 1586.82 | 5 MG
Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM. It is for research use only and has not been fully validated for medical applications.
- 11-residue cell-permeable cyclic peptide
- Orthosterically inhibits Ras-Raf protein interaction
- IC50 of 120 nM
- For research use only
Medchemexpress LLC Ncgc00138783 TFA | 00-00-0 | 99.4% | 617.62 g·mol⁻¹ | C28H27F4N7O3S | 5 MG
NCGC00138783 TFA is a small-molecule inhibitor that selectively targets the CD47/SIRPα immune checkpoint, blocking the CD47-SIRPα interaction with reported in vitro activity (IC50 ≈ 50 μM). Supplied as the trifluoroacetic acid (TFA) salt for research applications.
- Selective inhibitor of the CD47/SIRPα immune checkpoint.
- Reported IC50 approximately 50 μM in biochemical assays.
- Supplied as the trifluoroacetic acid (TFA) salt.
- High purity (99.4%).
- Molecular weight 617.62 g·mol⁻¹.
- Store at 4 °C; protect from moisture and light.
Medchemexpress LLC Thymotrinan | 00-00-0 | MFCD00237286 | 98.7% | 531.48 g·mol⁻¹ | C18H32F3N7O8 | 5 MG
Thymotrinan TFA is the trifluoroacetate (TFA) salt of a biologically active fragment of the thymus hormone thymopoietin. It exhibits immunomodulatory activity similar to TP5, affecting both humoral and cellular immune responses, and is supplied as a white to off-white solid for research use. Manufacturer storage and handling guidelines should be followed.
Medchemexpress LLC Cpn-351 TFA | 912.11 (free base) | 1 MG
CPN-351 TFA (compound 9a) is a pentapeptide that acts as a selective antagonist of human NMUR1. Its antagonistic effect on human NMUR1 is 10 times higher than on NMUR2, making it useful in the study of inflammation.
- Selective antagonist of human NMUR1
- Antagonistic effect is 10 times higher on NMUR1 than NMUR2
- Can be used in the study of inflammation
- pA2 of 7.35 for NMUR1
- Kb of 45 nM for NMUR1
Medchemexpress LLC Dendrotoxin K TFA | 99.5% | 6559.66 (free base) | 1 MG
Dendrotoxin K TFA is a Kv1.1 channel blocker. It determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform.
- Kv1.1 channel blocker
- Determines glutamate release in CA3 neurons
- Controls presynaptic spike waveform
Medchemexpress LLC Hth-01-091 Tfa | 2000209-42-5 | 98.64% | 499.43 | 1 MG
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. It also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2. This compound can be used for breast cancer research.
- Potent and selective MELK inhibitor.
- Inhibits multiple kinases including PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2.
- Suitable for breast cancer research.
Medchemexpress LLC DPC-AJ1951 TFA | 99.4% | 1666.99 (free base) | 5 MG
This 14 amino acid peptide acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption.
- Potent agonist of parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo bone resorption assays
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with human PPR
Medchemexpress LLC Atwlppr peptide tfa | 98.6% | 954.00 | 5 MG
ATWLPPR Peptide TFA is a heptapeptide that acts as a selective neuropilin-1 inhibitor. It prevents VEGF165 binding to NRP-1 and is utilized in angiogenesis research, showing promise in reducing early retinal damage associated with diabetes.
- Inhibits VEGF165 binding to neuropilin-1 by 82% at 100 μM
- Preserves vascular integrity and reduces oxidative stress in vivo
- May decrease early retinal damage associated with diabetes
- Prevents increase of inflammation-associated proteins in the retina
Medchemexpress LLC FTO-IN-1 TFA | 2797619-81-7 | 98.1% | 505.27 | 1 ML
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32. It can be used for the research of cancer and is for research use only.
- FTO inhibitor with an IC50 of <1 μM
- Inhibits FTO enzyme activity by 62% in vitro at 50 μM
- Inhibits the viability of SCLC-21H, RH30 and KP3 cells with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively
Medchemexpress LLC Valylleucine TFA (Val-Leu TFA) | 27530-02-5 | 99.3% | 344.33 | 5 MG
Valylleucine TFA is a polypeptide identified through peptide screening. Peptide screening serves as a research tool, primarily utilizing immunoassay to pool active peptides. This process is useful for studying protein interaction, functional analysis, and epitope screening, particularly in the development of agents.
- Identified through peptide screening
- Research tool primarily using immunoassay to pool active peptides
- Useful for studying protein interaction, functional analysis, and epitope screening
- Solutions should be aliquoted and stored to prevent inactivation from repeated freeze-thaw cycles
- If water is used as stock solution, dilute to working solution, then filter and sterilize with a 0.22 μm filter before use
Medchemexpress LLC GHRF, mouse TFA (mouse growth hormone-releasing factor TFA) | 98.9% | 5032.74 | 25 MG
GHRF, mouse TFA is a mouse growth hormone-releasing factor. It is a peptide composed of 44 amino acids. This substance stimulates the release and synthesis of growth hormone. It is intended for research use only and not for sale to patients.
- Appearance: white to off-white solid
- Stimulates release and synthesis of growth hormone
- Suitable for research use only
- Peptide sequence: His-Val-Asp-Ala-Ile-Phe-Thr-Thr-Asn-Tyr-Arg-Lys-Leu-Leu-Ser-Gln-Leu-Tyr-Ala-Arg-Lys-Val-Ile-Gln-Asp-Ile-Met-Asn-Lys-Gln-Gly-Glu-Arg-Ile-Gln-Glu-Gln-Arg-Ala-Arg-Leu-Ser
- Store sealed, away from moisture
- Powder storage: -80°C for 2 years; -20°C for 1 year
- In-solvent storage: -80°C for 6 months; -20°C for 1 month
- In vitro solubility in DMSO: 100 mg/mL (requires ultrasonic)
- Comprehensive documentation available
Medchemexpress LLC Alvespimycin (17-DMAG) trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g/mol | C34H49F3N4O10 | 5 MG
Alvespimycin TFA is the trifluoroacetate salt of 17-DMAG, a small-molecule inhibitor of heat shock protein 90 (Hsp90) used as a research reagent to study Hsp90-dependent signaling and anticancer mechanisms. The compound binds Hsp90 with an EC50 of 62 nM and is supplied as a high-purity, pale purple solid for laboratory use.
- Potent Hsp90 inhibitor (EC50 62 nM).
- Trifluoroacetate (TFA) salt form for consistent handling.
- High purity (reported ~98.97%).
- Molecular weight 730.77 g/mol.
- Pale purple solid appearance.
- Storage: sealed, away from moisture and light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Bio-AMS TFA | 1393881-52-1 | 98.0% | 685.65 | 1 MG
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. It exhibits selective activity against *Mycobacterium tuberculosis* (Mtb) and hinders fatty acid and lipid biosynthesis. It is for research use only and not sold to patients.
- Potent bacterial biotin protein ligase inhibitor.
- Selective activity against *Mycobacterium tuberculosis* (Mtb).
- Arrests fatty acid and lipid biosynthesis.
- Excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM.
- Its activity is not affected by changes to the primary carbon source.
- Inhibits growth of Mtb in Mtb-infected mouse macrophages in a concentration-dependent manner (2.5, 5 and 10 μM; 24 h).
- Shows no signs of mitochondrial toxicity.
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 1 ML
Ceftolozane TFA is a cephalosporin-class antibiotic supplied as a 10 mM solution in DMSO (1 mL). It is intended for use in antibacterial research, analytical method development, and as a building block for synthesis of novel antibiotics. Trifluoroacetate salt; molecular formula C25H31F3N12O10S2; molecular weight 780.71 g/mol.
- Provided as a ready-to-use 10 mM solution in DMSO.
- Suitable for antibacterial activity assays and analytical method development.
- Useful as a synthetic intermediate and reference standard for research.
- High purity suitable for analytical and preparative applications.
- Supplied in a 1 mL vial for small-scale experiments.
Medchemexpress LLC Cl2e-SN-38 TFA | 99.5% | 1855.95 | C89H117F3N14O26 | 1 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) linker-payload provided as the trifluoroacetate (TFA) salt. It incorporates SN-38, the active metabolite of irinotecan, and is intended for research use in ADC development and preclinical studies.
- Highly releasable linker-SN-38 conjugate suitable for ADC research.
- Provided as the trifluoroacetate salt to aid handling and formulation.
- Molecular weight 1855.95 and formula C89H117F3N14O26.
- High purity (reported ~99.5%).
- Available in milligram-scale quantities for assay development and conjugation experiments.